HYDRAULIC SURGICAL CEMENT

• Main Authors: BOHNER, MARC, LEMAITRE, JAQUES, VAN LANDUYT, PASCALE
• Format: Patent
• Language: English; French
• Published: 15.04.1999
• Edition: 6
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

The cement for surgical purposes comprises three components. The first component comprises beta tertiary calciumphosphate .beta.-Ca3(PO4)2 (.beta.-TCP) particles; and monocalcium phosphate Ca(H2O4)2 (MCPA) or monocalcium phosphate monohydrate Ca(H2PO4).H2O (MCPM) particles or phosphoric acid. The second component comprises water. The third component comprises particles having an average diameter which is larger than the average diameter of said beta tertiary calciumphosphate .beta.-Ca3(PO4)2 (.beta.-TCP) particles of said first component. Upon mixing of said three components a hardened mass comprising brushite CaHPO4. 2H2O (DCPD) is formed. The .beta.-TCP particles have a specific surface area of less than 10,000 m2/g and a Ca/P atomic ratio different from 1,50. The component constitutes 1 to 99 volume-percent of said hardened mass. The cements according to the invention may be used in dental and maxillofacial surgery (alveolar ridge reconstruction, dental socket filling), for orthopaedic applications (bone fracture repair, bone augmentation) and for local drug delivery (antibiotics, anti-inflammatory and anti-cancer drugs).