PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-CANCER COMPOUNDS

• Main Authors: SANTAFIANOS, DINOS PAUL, NORRIS, TIMOTHY, LEHNER, RICHARD SHELTON
• Format: Patent
• Language: English; French
• Published: 17.02.2004
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS THEREFOR; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FERROUS OR NON-FERROUS ALLOYS; FISHING; FORESTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PRETREATMENT OF RAW MATERIALS; PRODUCTION AND REFINING OF METALS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING; TREATMENT OF ALLOYS OR NON-FERROUS METALS

The present invention relates to methods and intermediates for preparing compounds of the formula 1 and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R1 and R2 are each independently selected from C1-C10 alkyl and C1-C10 alkoxy wherein said alkyl and alkoxy are optionally substituted by up to 2 substitutents independently selected from hydroxy and C1-C6 alkoxy; R15 is H, C1-C10 alkyl, or - (CH2)q(C6-C10 aryl), wherein q is an integer from 0 to 4. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals.