METHOD FOR THE PREPARATION OF CITALOPRAM

Method for the preparation of citalopram comprising reaction of a compound o f Formula IV (see formula IV) wherein R is halogen, or CF3-(CF2)n-SO2-, n being 0 to 8, with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cu+ or Zn2+, or with Zn(CN)2 in the presence a...

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Bibliographic Details
Main Authors ROCK, MICHAEL HAROLD, SVANE, HENRIK, PETERSEN, HANS
Format Patent
LanguageEnglish
French
Published 25.01.2005
Edition7
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Method for the preparation of citalopram comprising reaction of a compound o f Formula IV (see formula IV) wherein R is halogen, or CF3-(CF2)n-SO2-, n being 0 to 8, with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cu+ or Zn2+, or with Zn(CN)2 in the presence a palladium catalyst.
Bibliography:Application Number: CA19992290127