NEW 4-SUBSTITUTED PIPERIDINES

New 4-substituted piperidines New 4-substituted piperidines of general formula (I) arc described in which R1 and R2 are aryl radicals, substituted or not, which are obtained as racemic mixtures and as pure enantiomers. (SEE FORMULA I) These compounds, and their pharmaceutically acceptable salts, inh...

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Main Authors TOLEDO AVELLO, ANTONIO, PUMAR DURAN, CARMEN, ORJALES VENERO, AURELIO
Format Patent
LanguageEnglish
French
Published 06.01.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New 4-substituted piperidines New 4-substituted piperidines of general formula (I) arc described in which R1 and R2 are aryl radicals, substituted or not, which are obtained as racemic mixtures and as pure enantiomers. (SEE FORMULA I) These compounds, and their pharmaceutically acceptable salts, inhibit serotonin and/or noradrenaline reuptake, and are useful as antidepressants. Other potential therapeutic applications of these compounds are treatment of nervous bulimia, obsessive-compulsive disorders, alcohol addiction, anxiety, panic, pain, pre-menstrual syndrome and social phobia, a s well as migraine prophylaxis.
Bibliography:Application Number: CA19992288533