EGF-LIKE FACTOR FROM CHROMAFFIN GRANULES AND GLIA CELL-DERIVED NEUROTROPHIC FACTOR WITH SURVIVAL-PROMOTING ACTIVITY ON DAERGIC NEURONS

• Main Authors: GACK, SABINE, PAULISTA, MICHAEL, POHL, JENS, UNSICKER, KLAUS, BECHTOLD, ROLF
• Format: Patent
• Language: English; French
• Published: 05.02.1998
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to chromaffin granule-derived EGF-like proteins that are involved in promoting survival of DAergic neurons, to nucleotide sequences encoding said proteins or a functionally active derivative or part thereof, and to processes for their preparation. The present invention relates further on to glia cell-derived neurotrophic factors that are capable of promoting survival of DAergic neurons, to nucleotide sequences encoding said factors or a functionally active derivative or part thereof, and to a process for their preparation.