MUSCARINIC ANTAGONISTS

Di-N-substituted piperazine or 1,4di-substituted piperidine compounds in accordance with formula (I) (including all isomers, salts, esters, and solvates), wherein Q, n, R, R1, R2, R3, R4, R21, R27, R28, X, an d Z are as defined herein are muscarinic antagonists useful for treating cognitive disorder...

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Bibliographic Details
Main Authors CHANG, WEI K, LOWE, DEREK B, KOZLOWSKI, JOSEPH A, DUGAR, SUNDEEP
Format Patent
LanguageEnglish
French
Published 04.09.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Di-N-substituted piperazine or 1,4di-substituted piperidine compounds in accordance with formula (I) (including all isomers, salts, esters, and solvates), wherein Q, n, R, R1, R2, R3, R4, R21, R27, R28, X, an d Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations with acetylcholinesterase inhibitors of compounds capable of enhancing acetylcholine release and having the above formula.
Bibliography:Application Number: CA19972258044