NOVEL PROTEIN BINDING TO OSTEOCLASTOGENESIS INHIBITORY FACTOR AND PROCESS FOR PRODUCING THE SAME

• Main Authors: TSUDA, EISUKE, YANO, KAZUKI, KINOSAKI, MASAHIKO, GOTO, MASAAKI, WASHIDA, NAOHIRO, YASUDA, HISATAKA, KOBAYASHI, FUMIE, TAKAHASHI, KEN, TOMOYASU, AKIHIRO, NAKAGAWA, NOBUAKI, SHIMA, NOBUYUKI, YAMAGUCHI, KYOJI, HIGASHIO, KANJI, MORINAGA, TOMONORI
• Format: Patent
• Language: English; French
• Published: 22.10.1998
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WINE

A novel protein binding to osteoclastogenesis inhibitory factor (OCIF) (OCIFbinding molecule; OBM). A DNA encoding the above protein; a protein having the amino acid sequence encoded by this DNA; a process for producing this protein by the genetic engineering technique; and medicinal compositions containing this protein. A method for screening a substance regulating the expression of the above protein, a substance inhibiting or modifying the biological activity of the above protein, or a receptor binding to the above protein and thus mediating its function with the use of the above protein and the DNA thereof; substances thus obtained; and medicinal compositions containing the substances thus obtained. An antibody against the above protein; a method for assaying the above protein by using the antibody; and drugs containing the antibody.