NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES

Disclosed are novel compounds of the formula: (see formula I) (wherein R1 is optionally substituted phenyl or pyridyl; R2 is phenyl or 5- or 6-membered heteroaryl; and R3 is H, halo, CN, NO2, CF3, alkyl or alkoxy) which are .alpha.-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor...

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Bibliographic Details
Main Authors WELCH, WILLARD MCKOWAN JR, ELLIOTT, MARK LEONARD
Format Patent
LanguageEnglish
French
Published 17.05.2005
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are novel compounds of the formula: (see formula I) (wherein R1 is optionally substituted phenyl or pyridyl; R2 is phenyl or 5- or 6-membered heteroaryl; and R3 is H, halo, CN, NO2, CF3, alkyl or alkoxy) which are .alpha.-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and are useful as medicine for treating neurodegenerative and CNS-trauma related conditions.
Bibliography:Application Number: CA19972252907