CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS

• Main Authors: ANDRASI, FERENC, ABRAHAM, GIZELLA, SOLYOM, SANDOR, GAL, MELINDA, HAMORI, TAMAS, TARNAWA, ISTVAN, CSUZDI, EMESE, SZENTKUTI, ESZTER, SIMAY, ANTAL, PALLAGI, ISTVAN, LING, ISTVAN, SZOLLOSY, MARTA, BERZSENYI, PAL, HORVATH, KATALIN
• Format: Patent
• Language: English; French
• Published: 04.10.2005
• Edition: 6
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean -O-(CH2)n-O-; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member heterocycle which can contain between 1 and 3 nitrogen atoms and/or an oxygen atom and/or one or two carbonyl groups. Owing to their non- competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.