CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS

The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean -O-(CH2)n-O-; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member he...

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Main Authors ANDRASI, FERENC, ABRAHAM, GIZELLA, SOLYOM, SANDOR, GAL, MELINDA, HAMORI, TAMAS, TARNAWA, ISTVAN, CSUZDI, EMESE, SZENTKUTI, ESZTER, SIMAY, ANTAL, PALLAGI, ISTVAN, LING, ISTVAN, SZOLLOSY, MARTA, BERZSENYI, PAL, HORVATH, KATALIN
Format Patent
LanguageEnglish
French
Published 04.10.2005
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean -O-(CH2)n-O-; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member heterocycle which can contain between 1 and 3 nitrogen atoms and/or an oxygen atom and/or one or two carbonyl groups. Owing to their non- competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.
Bibliography:Application Number: CA19972245539