NOVEL PYRIDINECARBOXAMIDE DERIVATIVES

Pyridinecarboxamide derivatives represented by general formula (1) or physiologically acceptable salts thereof, wherein n represents an integer of 14 to 18; and R represents hydrogen or a C1 to C4 linear or branched alkyl. These compounds are excellent in the effects of inhibiting cerebral edema, pa...

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Main Authors NISHIMURA, KAZUMI, SAKAI, HIROSHI, MURAKI, YUKIKO, YOKOYAMA, SHINJI, OSHIDA, NORIO, ITOH, KOICHI, SAKURAI, EINOSUKE, TONOIKE, TOMOMI, SATOH, HIROAKI, HAMADA, TAMIKO, SUGAI, TOSHIJI, MIMAKI, YOJI
Format Patent
LanguageEnglish
French
Published 28.05.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Pyridinecarboxamide derivatives represented by general formula (1) or physiologically acceptable salts thereof, wherein n represents an integer of 14 to 18; and R represents hydrogen or a C1 to C4 linear or branched alkyl. These compounds are excellent in the effects of inhibiting cerebral edema, particularly ischemic cerebral edema, and inhibiting delayed neuron death (or inhibiting calcium inflow into neuros). They are useful as a cerebral edema inhibitor or a cerebrovascular disorder remedy, because cerebral edema is a pathological condition accompanying cerebrovascular disorder, particularly one observed in an acute stage. Because also they do not cause hypotension and scarely exhibit behavior suppressing activity, both believed to be side effects in the therapy of cerebrovascular disorder in an acute stage, they are especially excellent as a remedy therefor. In addition, they have the effects of protecting the brain (i.e., an antianoxic effect), increasing cerebral blood flow, and inhibiting lipid peroxidation, which further enhance the usefulness as a cerebrovascular disorder remedy.
Bibliography:Application Number: CA19972243427