PROCESS FOR MAKING A CYCLODEXTRIN

Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the pr esence of a base. The base is added in a stepwise, pH controlled manner so that substant ially the entire initial charge of cyclodextrin starting mater...

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Bibliographic Details
Main Authors SHAH, BHARAT KIRITKUMAR, SKLAVOUNOS, CONSTANTINE
Format Patent
LanguageEnglish
French
Published 25.06.2002
Edition6
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the pr esence of a base. The base is added in a stepwise, pH controlled manner so that substant ially the entire initial charge of cyclodextrin starting material is at least part ially reacted. Additional base is then added to complete the reaction, and residual alkyl s ultone is destroyed. The product advantageously contains low levels of both residual cyclodextrin and residual alkyl sultone.
Bibliography:Application Number: CA19982241774