A NOVEL PURINE DERIVATIVE

• Main Authors: HIROTA, KOHSAKU, SATOH, HARUMI, TAKAKU, HARUO, OGITA, HARUHISA, CHIBA, NOBUYOSHI, ISOBE, YOSHIAKI, MATSUI, HIROYUKI
• Format: Patent
• Language: English; French
• Published: 15.01.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Purine derivatives represented by general formula (I), their tautomers or pharmaceutically acceptable salts thereof, and interferon secretion inducers, antiviral agents and anticancer drugs containing the same. In said formula (I) R2 represents hydrogen or hydrocarbyl (wherein -CH2- not directly bonded to the purine skeleton and CH2 in -CH3 not directly bonded to the purine skeleton may be replaced by carbonyl, sulfonyl, -O- or -S-; =CH2 may be replaced by =O or =S; and C-H in -CH2 not directly bonded to the purine skeleton, C-H in -CH3 not directly bonded to the purine skeleton, C-H in CH not directly bonded to the purine skeleton, C-H in =CH- not directly bonded to the purine skeleton and C-H in =CH2 may be replaced by N, C-halogeno or C-CN); R6 represents hydroxy or amino optionally substituted by one or two hydrocarbon groups; R8 represents hydroxy, mercaptor, acyloxy or oxycarbonyl substituted by hydrocarbyl; and R9 represents hydrocarbyl (wherein -CH2- not directly bonded to the purine skeleton and CH2 in -CH3 not directly bonded to the purine skeleton may be replaced by carbonyl, sulfonyl, -O- or -S-; =CH2 may be replaced by =O or =S; and C-H in -CH2 not directly bonded to the purine skeleton, C-H in -CH3 not directly bonded to the purine skeleton, C-H in > CH not directly bonded to the purine skeleton, C-H in =CH- not directly bonded to the purine skeleton, C-H in =CH2 and C-H in CH may be replaced by N, Chalogeno or C-CN).