C-2' HYDROXYL-BENZYL PROTECTED, N-CARBAMATE PROTECTED (2R,3S)-3-PHENYLISOSERINE AND PRODUCTION PROCESS THEREFOR

The invention relates to the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side cha in acid to produce an intermediate that may thereafter be acylated and deprotected to produce paclitaxel.

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Bibliographic Details
Main Authors SWINDELL, CHARLES S, CHANDER, MADHAVI C, SISTI, NICHOLAS J
Format Patent
LanguageEnglish
French
Published 05.08.2008
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side cha in acid to produce an intermediate that may thereafter be acylated and deprotected to produce paclitaxel.
Bibliography:Application Number: CA19962222421