MODULATORS OF MULTI-DRUG RESISTANCES

The present invention relates to imidazole derivatives having formula 1 (see fig. I) wherein: R1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the substituents are selected from the group consisting of: (i) substituted C1-6 alkyl, substituted C2-6 alkylox...

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Bibliographic Details
Main Authors MJALLI, ADNAN M.M, SARSHAR, SEPEHR
Format Patent
LanguageEnglish
French
Published 25.10.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to imidazole derivatives having formula 1 (see fig. I) wherein: R1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the substituents are selected from the group consisting of: (i) substituted C1-6 alkyl, substituted C2-6 alkyloxy, wherein the substituents are selected from the group consisting of hydrogen or C1-6 alkoxy; (ii) C1-11 CO2R5, trans- CH=CHCO2R5, wherein R5 is C1-11 alkyl, or phenyl C1-11 alkyl; R2 and R3 are mono-, di, and tri-substituted phenyl wherein the substituents are independently selected from: (i) halo; (ii) C1-6 alkyl-amino, or di(C1-6 alkyl)amino, and R4 is hydrogen. These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic agents.
Bibliography:Application Number: CA19972207753