PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED 5-CHLOROIMIDAZOLE-4-CARBALDEHYDES

A novel process for the preparation of 2-substituted 5- chloroimidazole-4-carbaldehydes of the general formula: (see formula I) wherein R denotes hydrogen, alkyl, alkenyl, cycloalkyl, arylalkyl or aryl, in which glycine is reacted with an imido ester of the general formula: (see formula II) wherein...

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Bibliographic Details
Main Authors STUCKY, GERHARD CHRISTIAN, GRIFFITHS, GARETH JOHN
Format Patent
LanguageEnglish
French
Published 12.07.2005
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A novel process for the preparation of 2-substituted 5- chloroimidazole-4-carbaldehydes of the general formula: (see formula I) wherein R denotes hydrogen, alkyl, alkenyl, cycloalkyl, arylalkyl or aryl, in which glycine is reacted with an imido ester of the general formula: (see formula II) wherein R is as above and R1 is alkyl, and the resulting intermediate is converted into the target product by a Vilsmeier reagent. The 2-substituted 5-chloroimidazole-4- carbaldehydes (I) are valuable intermediates in the preparation of pharmaceuticals or of herbicidally active compounds.
Bibliography:Application Number: CA19962194119