RETROVIRAL GENE THERAPY VECTORS AND THERAPEUTIC METHODS BASED THEREON

Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rend...

Full description

Saved in:
Bibliographic Details
Main Authors RAFIELD, LORI F, RIVIERE, ISABELLE, MULLIGAN, RICHARD C, GUILD, BRAD, ROBBINS, PAUL, COHEN, LAWRENCE K
Format Patent
LanguageEnglish
French
Published 21.12.1995
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rendering them suitable for human gene therapy in the treatment of a variety of disease states without the co-expression of a marker product, such as an antibiotic. These retroviral vectors are especially suited for use in certain packaging cell lines. La présente invention concerne des vecteurs rétroviraux comportant un site d'insertion pour des gènes concernés. Ces vecteurs rétroviraux sont capables d'exprimer, dans une grande diversité de types de cellules transfectées, des niveaux élevés de la protéine dérivée des gènes concernés. L'invention concerne également des vecteurs rétroviraux ne comportant pas de marqueur sélectionnable, ce qui fait qu'ils conviennent chez l'homme pour le traitement par thérapie génique de divers états de maladies sans co-expression d'un produit marqueur tel qu'un antibiotique. Ces vecteurs rétroviraux conviennent particulièrement à certaines lignées cellulaires d'assemblage.
Bibliography:Application Number: CA19952191845