HUMAN INTERLEUKIN VARIANTS GENERATED BY ALTERNATIVE SPLICING

• Main Authors: WHITE, BARBARA, ALMS, WILLIAM J
• Format: Patent
• Language: English; French
• Published: 12.10.1995
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

Novel splice mutants of interleukins-2 and 4 are disclosed, which contain exons 1, 3 and 4 of the full-length mRNAs, but have exon 2 deleted. The proteins resulting from the expression of these splice mutants are useful in regulating the activity of the full-length interleukins. La présente invention concerne de nouveaux mutants des interleukines 2 et 4 obtenus par épissage, ces mutants comportant les exons 1, 3 et 4 des ARNm pleine longueur, auxquels il manque cependant l'exon 2. Les protéines issues de l'expression de ces mutants obtenus par épissage sont utiles pour la régulation de l'activité des interleukines pleine longueur.