RECOMBINANT ADENOVIRAL VECTOR AND METHODS OF USE

This invention provides a recombinant adenovirus expression vector character ized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant pr...

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Bibliographic Details
Main Authors MANEVAL, DANIEL C, GREGORY, RICHARD J, WILLS, KEN N
Format Patent
LanguageEnglish
French
Published 12.06.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:This invention provides a recombinant adenovirus expression vector character ized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, t he adenoviral vector of this invention can contain a foreign gene for the expre ssion of a protein effective in regulating the cell cycl e, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suic ide gene thymidine kinase. (The latter must be used in c onjunction with a thymidine kinase metabolite in order to be effective).
Bibliography:Application Number: CA19942173975