ANTIMICROBIAL INDOLE DERIVATIVES

The invention is drawn to an antibiotic, NEMATOPHIN, 3-indoleethyl 2-oxo- 3- methylbutanamide (+ stereoisomer, - stereoisomer and racemic mixture) and it s derivatives, 3- indoleethyl 2-oxo-alkanamides, 3-indoleethyl 2-oxo-alkanoates with or withou t substitute(s) on the indole ring, produced by bac...

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Bibliographic Details
Main Authors WEBSTER, JOHN M, CHEN, GENHUI, LI, JIANXIONG
Format Patent
LanguageEnglish
French
Published 15.04.2003
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPIRITS
VINEGAR
WINE
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Summary:The invention is drawn to an antibiotic, NEMATOPHIN, 3-indoleethyl 2-oxo- 3- methylbutanamide (+ stereoisomer, - stereoisomer and racemic mixture) and it s derivatives, 3- indoleethyl 2-oxo-alkanamides, 3-indoleethyl 2-oxo-alkanoates with or withou t substitute(s) on the indole ring, produced by bacterial symbiont Xenorhabdus nematophilus and/or other Xenorhabdus species or synthesized by reaction of tryptamine or substituted tryptamine a nd 2-oxo-alkanoic acid or its derivative, the salts thereof, the pharmaceutical compositions thereof a nd their use as medicaments. particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including antibiotic-resistant Staphylococcus.
Bibliography:Application Number: CA19962172854