RESOLUTION OF THE RACEMATES OF PRIMARY AND SECONDARY AMINES BY ENZYME-CATALYZED ACYLATION

A process for producing optically active primary and secondary amines from t he corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at...

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Main Authors HAUER, BERNHARD, PRESSLER, UWE, LADNER, WOLFGANG, BALKENHOHL, FRIEDHELM, NUBLING, CHRISTOPH
Format Patent
LanguageEnglish
French
Published 27.01.2009
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A process for producing optically active primary and secondary amines from t he corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon ato m; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produce d; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.
Bibliography:Application Number: CA19942170059