PROCESS FOR THE ISOLATION OF LOVASTATIN

There is disclosed a process for the isolation of the hypolipaemic active su bstance lovastatin from a sample, e.g. fermentation broth, mycelium or filtrate of Aspergillus terreus (ATCC 20542) or Aspergill us oryzae (ATCC 74135) by extraction with butyl acetate. Simultaneously with the concentration...

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Bibliographic Details
Main Authors VESEL, TANJA, POKORNY, MIROSLAV, HAJKO, PAVICA, RADEZ, IVAN
Format Patent
LanguageEnglish
French
Published 15.01.2002
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:There is disclosed a process for the isolation of the hypolipaemic active su bstance lovastatin from a sample, e.g. fermentation broth, mycelium or filtrate of Aspergillus terreus (ATCC 20542) or Aspergill us oryzae (ATCC 74135) by extraction with butyl acetate. Simultaneously with the concentration of the extract, lactonisation takes pl ace. There follows a direct crystallization of lovastati n in the lactone form from butyl acetate.
Bibliography:Application Number: CA19942164411