INCLUSION COMPLEXES OF TAXOL OR TAXOTERE OR TAXUS EXTRACT FORMED WITH CYCLODEXTRINS, ITS PREPARATION AND USE

The invention relates to the inclusion complexes of Taxol or Taxotere and Taxus extracts (comprising besides taxol other diterpene taxan-drivatives) formed with a cyclodextrin derivative or cyclodextrin- derivative-mixture. According to the invention, improved aqueous solubility of Taxol and Taxan-d...

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Bibliographic Details
Main Authors SZEJILI, JOZSEF, SZENTE, LAJOS, VIKMON, ANDRASNE
Format Patent
LanguageEnglish
French
Published 08.03.2005
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to the inclusion complexes of Taxol or Taxotere and Taxus extracts (comprising besides taxol other diterpene taxan-drivatives) formed with a cyclodextrin derivative or cyclodextrin- derivative-mixture. According to the invention, improved aqueous solubility of Taxol and Taxan-derivatives can be reached by using suitable cyclodextrins and/or cyclodextrin derivatives and/or mixtures thereof. The inclusion complexes can be prepared in an aqueous medium, in solid form or by high energy milling. The pharmaceutical compositions according to the invention bear an outstanding importance in treatment of cancer.
Bibliography:Application Number: CA19942162716