CARTRIDGE ASSEMBLY FOR A LYOPHILIZED COMPOUND FORMING A DISPOSABLE PORTION OF AN INJECTOR PEN AND METHOD FOR SAME

A cartridge assembly (90) for holding a lyophilized product, forming a disposable portion of a pen injector (104), includes a cylindrical glass cartridge (58) adapted to receive the product, a closure cap (20), a cartridge case (76), and a plunger mechanism. The closure cap (20) is adapted to retain...

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Bibliographic Details
Main Author HARRIS, DALE C
Format Patent
LanguageEnglish
French
Published 24.08.1999
Edition6
Subjects
BABY COMFORTERS
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES
DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR RECEIVING SPITTLE
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
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Summary:A cartridge assembly (90) for holding a lyophilized product, forming a disposable portion of a pen injector (104), includes a cylindrical glass cartridge (58) adapted to receive the product, a closure cap (20), a cartridge case (76), and a plunger mechanism. The closure cap (20) is adapted to retain an elastomeric disc seal (52) during lyophilization and includes diametrically opposed ledges (38, 40). The closure cap (20) and seal (52) are adapted to cover a neck portion of the ampule (58), the neck portion having on its end a radially extending circumferential flange (62). The ledges (38, 40) of the closure cap (20) and the flange (62) of the neck portion allow the closure cap (20) to remain open during lyophilization, oxygen purge and nitrogen overlay. An oval-shaped indentation formed on the inside of the closure cap (20) aids in snapping the closure cap (20) about the flange (62) without crimping to retain the closure cap (20) underneath the flange (62). Reconstitution of the lyophilized drug is accomplished without foaming by use of an obliquely angled connector (30) which causes the diluent to indirectly impinge on the drug. The injection pen (104) and cartridge assembly (90) cooperate such that the length of travel of the plunger rod (108) during retraction is less than the axial length of a recess (107) in the rod tip (73).
Bibliography:Application Number: CA19942157768