15-SUBSTITUTED 4-AZASTEROIDS

Compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 is -H or C1-10 alkyl; R2 is -H or C1-10 alkyl; R3 is C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxyl, cyano, or triphenylthioC1-6 alkyl; and R4 is a mono-substituent or di-substituent are useful as inhibitors of 5....

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Bibliographic Details
Main Authors HAGMANN, WILLIAM, KOPKA, IHOR E, ESSER, CRAIG K, DURETTE, PHILIPPE L
Format Patent
LanguageEnglish
French
Published 15.09.1994
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 is -H or C1-10 alkyl; R2 is -H or C1-10 alkyl; R3 is C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxyl, cyano, or triphenylthioC1-6 alkyl; and R4 is a mono-substituent or di-substituent are useful as inhibitors of 5.alpha.-reductase. These compounds can be used alone or in combination with other active agents to treat acne, androgenic alopecia, female hirsutism, benign prostatic hyperplasia, prostatitis, and treat and prevent prostatic carcinoma.
Bibliography:Application Number: CA19942157363