Process for the Preparation of Propargyl Ammonium-Chloride Derivatives

Method for the prepn. of L-isomers of propargyl ammonium chloride derivs. of formula (I) involves: (a) treatment of the D-tartrate of the L-isomer of a secondary amine with an aq. soln. of NH4OH or basic alkaline salt and/or ammonium salt to release the amine (II); (b) reaction with 1-1.5 mol. equiv...

Full description

Saved in:
Bibliographic Details
Main Authors SZILADI, MARIA, NAD, ZSUZSANNA, MONTAY, TIBOR, KALLAY, TAMAS
Format Patent
LanguageEnglish
French
Published 23.05.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:Method for the prepn. of L-isomers of propargyl ammonium chloride derivs. of formula (I) involves: (a) treatment of the D-tartrate of the L-isomer of a secondary amine with an aq. soln. of NH4OH or basic alkaline salt and/or ammonium salt to release the amine (II); (b) reaction with 1-1.5 mol. equivs. of a propargyl halide (V) at 0-50 [deg]C at pH 8-12 to give the alkylated free base (III); (c) treatment with aq. NH4OH and/or aq. phosphate salt of pH 5.5-7.5 to remove unreacted (II) and other impurities; (d) distillation of the organic layer to obtain pure (III); and (e) conversion of (III) to the HCl salt (I): X = halo; and Y = H or F.
Bibliography:Application Number: CA19942137761