STYRYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION

Compounds of general formula (1) are described, wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R6)-, where R6 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group;...

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Bibliographic Details
Main Authors BOYD, EWAN CAMPBELL, WARRELLOW, GRAHAM JOHN, ALEXANDER, RIKKI PETER
Format Patent
LanguageEnglish
French
Published 02.11.2004
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of general formula (1) are described, wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R6)-, where R6 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 and R4, which may be the same or different, is each a group -(CH2)n Ar, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1, 2 or 3; R5 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are pout, selective and orally active PDE IV inhibitors and are useful in the prophylaxis and treatment of asthma and other diseases.
Bibliography:Application Number: CA19932129040