RECOMBINANT VIRUS EXPRESSING CARCINOEMBRYONIC ANTIGEN AND METHODS OF USE THEREOF

• Main Authors: SCHLOM, JEFFREY, KANTOR, JUDITH
• Format: Patent
• Language: English; French
• Published: 07.11.1992
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a recombinant carcinoembryonic antigen (CEA)/vaccinia virus or other viral vector which expresses GEA on the surface of infected cells and which elicits an immune response in vivo directed against CEA or cells ex- pressing CEA an d a pharmaceutical composition containing same. The inventio n also relates to methods of treating patients con- taining carcinoma cells in which CEA is expressed and methods of stimulating the immune system against CEA. 2102623 9219266 PCTABS00017 The present invention relates to a recombinant carcinoembryonic antigen (CEA)/vaccinia virus or other viral vector which expresses CEA on the surface of infected cells and which elicits an immune response in vivo directed against CEA or cells expressing CEA an d a pharmaceutical composition containing same. The invention also relates to methods of treating patients containing carcinoma cells in which CEA is expressed and methods of stimulating the immune system against CEA.