PREPARATION OF (7S, TRANS)-2-(2-PYRIMIDINYL)-7-(HYDROXYMETHYL) OCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZINE

A process for separating the enantiomers (I), (II) of a racemic mixture of trans -2-(2-pyrimidinyl)-7-(hydroxymethyl) octa-hydro-2H-pyrido¢1,2-a!pyrazine comprising reacting the racemic mixture with D-(-) or L-( + ) tartaric acid and separating the resulting diastereomeric tartrate salts.

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Bibliographic Details
Main Author MURTIASHAW, CHARLES W
Format Patent
LanguageEnglish
French
Published 29.09.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for separating the enantiomers (I), (II) of a racemic mixture of trans -2-(2-pyrimidinyl)-7-(hydroxymethyl) octa-hydro-2H-pyrido¢1,2-a!pyrazine comprising reacting the racemic mixture with D-(-) or L-( + ) tartaric acid and separating the resulting diastereomeric tartrate salts.
Bibliography:Application Number: CA19912099563