Microbiological Process for Preparing Mevinolin

• Main Authors: VARGA, ILONA, NAGY, KAROLY, ERDEI, JANOS, CSEKE, LASZLO, SANTHA, GYOERGY, KISS, LAJOS, KISS, ANDRAS, KASZAS, MIHALY, ILKOY, EVA, ANDOR, ATTILA, MORAVCSIK, IMRE, SZABO, ISTVAN M, SZABO, ISTVAN, HALASZ, EDIT, POLYA, KALMAN, MAGYI, ISTVAN, JEKKEL, ANTONIA, AMBRUS, GABOR
• Format: Patent
• Language: English; French
• Published: 18.12.1993
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; SPIRITS; VINEGAR; WINE

The invention refers to a new microbial process for preparing beta , delta -dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]-heptanoic acid delta -lactone of formula (I) and beta , delta -dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), (I) (II) by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25 DEG to 30 DEG C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.