CELL LINE AND ASSAY TO DETERMINE BIOLOGICAL ACTIVITY OF RETINOIDS
The present invention relates to an assay and cell lines for determining the biological effects of retinoids. The cell line is derived from a human lung tumour line which is tumorigenic in nude mice and expressed undetectable levels of the .beta. receptor of retinoic acid by introducing in a stable...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
29.07.1994
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| Edition | 5 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to an assay and cell lines for determining the biological effects of retinoids. The cell line is derived from a human lung tumour line which is tumorigenic in nude mice and expressed undetectable levels of the .beta. receptor of retinoic acid by introducing in a stable fashion the DNA coding for this receptor. The novel line is nontumorigenic and grows in culture at a rate which is reduced in the presence of 10-7 M retinoic acid. This line is useful in determining the biological effects of novel retinoids which act in particular by activating RAR.beta.. |
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| AbstractList | The present invention relates to an assay and cell lines for determining the biological effects of retinoids. The cell line is derived from a human lung tumour line which is tumorigenic in nude mice and expressed undetectable levels of the .beta. receptor of retinoic acid by introducing in a stable fashion the DNA coding for this receptor. The novel line is nontumorigenic and grows in culture at a rate which is reduced in the presence of 10-7 M retinoic acid. This line is useful in determining the biological effects of novel retinoids which act in particular by activating RAR.beta.. |
| Author | BRADLEY, W. EDWARD C HOULE, BENOIT BELOUCHI, ABDELMAJID |
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| Discipline | Medicine Chemistry Sciences Physics |
| DocumentTitleAlternate | LIGNEE CELLULAIRE ET ESSAI POUR LA DETERMINATION DE L'ACTIVITE BIOLOGIQUE DES RETINOIDES |
| Edition | 5 |
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| Notes | Application Number: CA19932088293 |
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| PublicationDate | 19940729 |
| PublicationDateYYYYMMDD | 1994-07-29 |
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| PublicationYear | 1994 |
| RelatedCompanies | BRADLEY, W. EDWARD C HOULE, BENOIT BELOUCHI, ABDELMAJID |
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| Snippet | The present invention relates to an assay and cell lines for determining the biological effects of retinoids. The cell line is derived from a human lung tumour... |
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| SubjectTerms | CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING |
| Title | CELL LINE AND ASSAY TO DETERMINE BIOLOGICAL ACTIVITY OF RETINOIDS |
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