CELL LINE AND ASSAY TO DETERMINE BIOLOGICAL ACTIVITY OF RETINOIDS

The present invention relates to an assay and cell lines for determining the biological effects of retinoids. The cell line is derived from a human lung tumour line which is tumorigenic in nude mice and expressed undetectable levels of the .beta. receptor of retinoic acid by introducing in a stable...

Full description

Saved in:
Bibliographic Details
Main Authors BRADLEY, W. EDWARD C, HOULE, BENOIT, BELOUCHI, ABDELMAJID
Format Patent
LanguageEnglish
French
Published 29.07.1994
Edition5
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to an assay and cell lines for determining the biological effects of retinoids. The cell line is derived from a human lung tumour line which is tumorigenic in nude mice and expressed undetectable levels of the .beta. receptor of retinoic acid by introducing in a stable fashion the DNA coding for this receptor. The novel line is nontumorigenic and grows in culture at a rate which is reduced in the presence of 10-7 M retinoic acid. This line is useful in determining the biological effects of novel retinoids which act in particular by activating RAR.beta..
Bibliography:Application Number: CA19932088293