RECEPTOR DIRECTED-TOXIN CONJUGATES

2086679 9200762 PCTABS00010 The invention relates to a targeted toxin molecule comprising a toxin and a proteinaceaous molecule with binding activity for a receptor on the surface of a target cell, whereby the proteinaceous molecule is the ligand on a functional derivative or fragment thereof and th...

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Bibliographic Details
Main Authors VERHEUL, HERMANUS A. M, BOS, EBO S
Format Patent
LanguageEnglish
French
Published 06.01.1992
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:2086679 9200762 PCTABS00010 The invention relates to a targeted toxin molecule comprising a toxin and a proteinaceaous molecule with binding activity for a receptor on the surface of a target cell, whereby the proteinaceous molecule is the ligand on a functional derivative or fragment thereof and the toxin has a molecular weight of no more than 1500 D. More specifically the ligand is IL-2, or preferably only its binding domain. The toxin may be any small toxin, for instance calicheamycin, verrucarin etc.. The toxin molecules according to the invention localize faster and are less immunogenic.
Bibliography:Application Number: CA19912086679