IMPROVED CYCLODEXTRIN BASED ERYTHROPOIETIN FORMULATION

2074820 9111200 PCTABS00006 The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a .beta.-/ or .gamma.-cyclodextrin hydroxyalkyl derivative. The invention also relates to novel lyophilized or sp...

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Bibliographic Details
Main Authors MESENS, JEAN L, KONINGS, FRANK J, NOPPE, MARCUS J. M
Format Patent
LanguageEnglish
French
Published 30.07.1991
Edition5
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:2074820 9111200 PCTABS00006 The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a .beta.-/ or .gamma.-cyclodextrin hydroxyalkyl derivative. The invention also relates to novel lyophilized or spray-dried erythropoietin compositions comprising a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative, to processes for preparing such aqueous, lyophilized or spray-dried compositions and to a method for simultaneously stabilizing erythropoietin in an aqueous solution and preventing it from being adsorbed to surfaces.
Bibliography:Application Number: CA19912074820