METHODS FOR DIAGNOSING HUMAN INFLUENZA AND 4-POSITION MODIFIED CHROMOGENIC N-ACETYLNEURAMINIC ACID SUBSTRATES FOR USE THEREIN

Chromogenic derivatives of N-acetylneuraminic acid modified in the 4-position by eliminating the hydroxyl group, by replacing the hydroxyl group with fluorine, or by replacing the hydrogen of the hydroxyl group with methyl are used as substrates in colorimetric assays for human influenza neuraminida...

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Bibliographic Details
Main Authors TURNER, GREGORY A, MAHER, JAMES F, ROARK, MICHAEL D, CLINKSCALES, C. WORTH
Format Patent
LanguageEnglish
French
Published 30.06.1998
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
DERIVATIVES THEREOF
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
SUGARS
TESTING
VINEGAR
WINE
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Summary:Chromogenic derivatives of N-acetylneuraminic acid modified in the 4-position by eliminating the hydroxyl group, by replacing the hydroxyl group with fluorine, or by replacing the hydrogen of the hydroxyl group with methyl are used as substrates in colorimetric assays for human influenza neuraminidase activity in clinical sp ecimens for the purpose of selectively diagnosing influenza infection. The substrates may exhibit different reactivity with the d ifferent types of influenza neuraminidases, thus enabling one to discern the specific type of influenza infection and prescribe a ppropriate treatment and/or supportive therapy therefor.
Bibliography:Application Number: CA19902072368