NAPHTHALENE DERIVATIVES

• Main Authors: YAMATSU, ISAO, MIYAZAWA, SHUHEI, HARADA, KOUKICHI, OKANO, KAZUO, CHIBA, KENICHI, HORIE, TORU, MORI, TAKASHI, YOSHIMURA, HIROYUKI, HASHIDA, RYOICHI, MURAMOTO, KENZO, SHIROTA, HIROSHI, KUSUBE, KENICHI, INOUE, TAKASHI, CLARK, RICHARD, S. J, KAWAHARA, TETSUYA, ABE, SHINYA, SHIMOMURA, NAOYUKI, SUZUKI, TAKESHI
• Format: Patent
• Language: English; French
• Published: 17.05.1992
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel naphthalene derivatives and pharmacologically acceptable salts thereof, having excellent anti-inflammatory activity, are disclosed. The naphthalene derivatives fall within the general formula: (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group; R3 stands for a hydroxyl group, an ester-forming group or an amine; R4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula: (wherein p is 0 or an integer 1 to 3, and R12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group); z stands for a group represented by the formula: (wherein R5 and R6 may be the same or different from each other and each stands, by way of example, for a hydrogen atom or a lower alkyl group), a group represented by the formula: =N-OR7 (wherein R7 stands for a lower alkyl group) or an oxygen atom; and Y stands for a group represented by the formula: -(CH2)n- (wherein n is 0 or an integer 1 or 2) or a group represented by the formula: (wherein R8 and R9 may be the same or different from each other and each stands for a lower alkyl group).