FIBROBLAST GROWTH FACTOR (FGF)-BASED STABILIZED COMPOSITIONS AND THE USE THEREOF

A novel stabilized composition is provided herein. The stabilized compositi on includes an agent having a cell and tissue regenerating activity. The agent comprises at least one functionalized, substituted dextran containing the following functions, namely carboxymethyl, benzylamide or benzylamide s...

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Main Authors COURTY, JOSE, TARDIEU, MICHELE, CARUELLE, JEAN-PIERRE, JOZEFONVICZ, JACQUELINE, SLAOUI, FAOUZI, BARRITAULT, DENIS
Format Patent
LanguageEnglish
French
Published 10.09.1990
Edition6
Subjects
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Abstract A novel stabilized composition is provided herein. The stabilized compositi on includes an agent having a cell and tissue regenerating activity. The agent comprises at least one functionalized, substituted dextran containing the following functions, namely carboxymethyl, benzylamide or benzylamide sulphonate, in association with at least one of the following: an acid FGF; a basic FGF; a derivative thereof; an analogu e thereof; a fragment thereof, the fragment thereof having a biological activity. The agent is capable of at least partially restoring the biological activity of the acid and/or basic FGF/FGFs which have been inactivated by prolonged storage or temperature. Novel uses for this stabilized composition are also provided. Agents having a cellular and tissular regenerating activity consisting of functionalized substituted dextrans, stabilized compositions containing said agents associated with at least one fibroblast growth factor (FGFs) such as a FGF acid and/or a basic FGF and/or a derivative and/or an analogue and/or a fragment of these disclosing a biological activity and their in vitro applications such as storing FGFs and cellular cultures and in vivo applications as a therapeutic agent, in particular for healing and tissular regeneration or as a cosmetic agent.
AbstractList A novel stabilized composition is provided herein. The stabilized compositi on includes an agent having a cell and tissue regenerating activity. The agent comprises at least one functionalized, substituted dextran containing the following functions, namely carboxymethyl, benzylamide or benzylamide sulphonate, in association with at least one of the following: an acid FGF; a basic FGF; a derivative thereof; an analogu e thereof; a fragment thereof, the fragment thereof having a biological activity. The agent is capable of at least partially restoring the biological activity of the acid and/or basic FGF/FGFs which have been inactivated by prolonged storage or temperature. Novel uses for this stabilized composition are also provided. Agents having a cellular and tissular regenerating activity consisting of functionalized substituted dextrans, stabilized compositions containing said agents associated with at least one fibroblast growth factor (FGFs) such as a FGF acid and/or a basic FGF and/or a derivative and/or an analogue and/or a fragment of these disclosing a biological activity and their in vitro applications such as storing FGFs and cellular cultures and in vivo applications as a therapeutic agent, in particular for healing and tissular regeneration or as a cosmetic agent.
Author JOZEFONVICZ, JACQUELINE
SLAOUI, FAOUZI
TARDIEU, MICHELE
CARUELLE, JEAN-PIERRE
BARRITAULT, DENIS
COURTY, JOSE
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– fullname: SLAOUI, FAOUZI
– fullname: BARRITAULT, DENIS
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DocumentTitleAlternate COMPOSITIONS STABILISEES CONTENANT DES FACTEURS DE CROISSANCE DES FIBROBLASTES (FGF) ET UTILISATION DE CELLES-CI
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Snippet A novel stabilized composition is provided herein. The stabilized compositi on includes an agent having a cell and tissue regenerating activity. The agent...
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SubjectTerms CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
Title FIBROBLAST GROWTH FACTOR (FGF)-BASED STABILIZED COMPOSITIONS AND THE USE THEREOF
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