FIBROBLAST GROWTH FACTOR (FGF)-BASED STABILIZED COMPOSITIONS AND THE USE THEREOF

• Main Authors: COURTY, JOSE, TARDIEU, MICHELE, CARUELLE, JEAN-PIERRE, JOZEFONVICZ, JACQUELINE, SLAOUI, FAOUZI, BARRITAULT, DENIS
• Format: Patent
• Language: English; French
• Published: 10.09.1990
• Edition: 6
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

A novel stabilized composition is provided herein. The stabilized compositi on includes an agent having a cell and tissue regenerating activity. The agent comprises at least one functionalized, substituted dextran containing the following functions, namely carboxymethyl, benzylamide or benzylamide sulphonate, in association with at least one of the following: an acid FGF; a basic FGF; a derivative thereof; an analogu e thereof; a fragment thereof, the fragment thereof having a biological activity. The agent is capable of at least partially restoring the biological activity of the acid and/or basic FGF/FGFs which have been inactivated by prolonged storage or temperature. Novel uses for this stabilized composition are also provided. Agents having a cellular and tissular regenerating activity consisting of functionalized substituted dextrans, stabilized compositions containing said agents associated with at least one fibroblast growth factor (FGFs) such as a FGF acid and/or a basic FGF and/or a derivative and/or an analogue and/or a fragment of these disclosing a biological activity and their in vitro applications such as storing FGFs and cellular cultures and in vivo applications as a therapeutic agent, in particular for healing and tissular regeneration or as a cosmetic agent.