CRYSTALLINE HYDROCHLORIDE OF NEW BETA-LACTAM ANTIBIOTIC AND PROCESS THEREFOR

The crystalline hydrochloride of the antibiotic 7.beta.-[2'-(R)-2'-phenyl-2'-aminoacetamido]-3-chloro-3-(1- carbadethiacephem)-4-carboxylic acid ("LY163892") is described. The crystalline hydrochloride is an antibiotic in its own right and is a valuable intermediate to the c...

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Bibliographic Details
Main Author PFEIFFER, RALPH R
Format Patent
LanguageEnglish
French
Published 05.06.2001
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The crystalline hydrochloride of the antibiotic 7.beta.-[2'-(R)-2'-phenyl-2'-aminoacetamido]-3-chloro-3-(1- carbadethiacephem)-4-carboxylic acid ("LY163892") is described. The crystalline hydrochloride is an antibiotic in its own right and is a valuable intermediate to the corresponding monohydrate form of LY163892. A process for preparing LY163892 crystalline hydrochloride is also provided.
Bibliography:Application Number: CA19912034592