BENZOFURAN DERIVATIVES

• Main Authors: ROSS, BARRY C, SCOPES, DAVID I. C, MIDDLEMISS, DAVID, CARDWELL, KEVIN S, DOWLE, MICHAEL D, JACK, TORQUIL I. M
• Format: Patent
• Language: English; French
• Published: 02.06.1991
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

BENZOFURAN DERIVATIVES The invention provides compounds of the general formula (l) (I) or a physiologically acceptable salt, solvate or non-toxic metabolically labile ester thereof wherein R1 represents a hydrogen atom or a halogen atom or a group selected from C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, C1-6alkoxy, -CHO, -CO2H or -COR2; Ar represents the group R2 represents a group selected irom C1-6alkyl, C2-6alkenyl, C1-6alkoxy or tlle group NR10R11; R3 represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R4 and R5, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a C1-6alkyl group; Het represents an N-linked imidazolyl group optionally substituted at the 2-position by a C1-6alkyl, C2-6alkenyl or a C1-6alkyltllio group, the imidazolyl group optionally being substituted at the 4- and 5- positions by one or two further substituents selected from a halogen atom or group selected from cyano, nitro, C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR6, -(CH2)nCOR7 or -(CH2)pNR8COR9; R6 represents a hydroxy or C1-6alkoxy group; R7 represents a hydrogen atom or a group selected from hydroxy, C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR10R11; R8 represents a hydrogen atom or a C1-6alkyl group; R9 represents a hydrogen atom or a group selected from C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR1OR1 1; R10 and R11, which may be the same or different, each independently represent a hydrogen atom or a C1-4alkyl group or -NR10R11 forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom; m represents an integer from 1 to 4; n represents an integer from 0 to 4; and p represents an integer from 1 to 4. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.