AMINOCARBONYLCARBAMATES RELATED TO PHYSOSTIGMINE, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments The present invention relates to various derivatives related to physostigmine of the formula I (see formula I) where Z is hydrogen, halogen or loweralkyl; R1 is loweralkyl, cycloalkyl or ar...

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Bibliographic Details
Main Authors HAMER, RUSSELL RICHARD LEE, GLAMKOWSKI, EDWARD JOSEPH, CHIANG, YULIN
Format Patent
LanguageEnglish
French
Published 23.01.2001
Edition5
Subjects
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Summary:Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments The present invention relates to various derivatives related to physostigmine of the formula I (see formula I) where Z is hydrogen, halogen or loweralkyl; R1 is loweralkyl, cycloalkyl or aryl; and R2 is loweralkyl or cycloalkyl; the 3aS-cis isomer or the 3aR-isomer thereof or a mixture of the two isomers including the racemic mixture, or a pharmaceutically acceptable acid addition salt thereof, and a process for their preparation. The compounds according to the invention are useful for enhancing cholinergic function, and as analgesic agents.
Bibliography:Application Number: CA19902031079