METHODS OF TREATING RETROVIRAL INFECTION

X-8100A The present invention provides antiretroviral methods using the compounds of formula (I) X-Xl-Pl-Val-Z-Leu-P2-Y wherein: Z is Statine or ACHPA; and when Z is Statine, X is H-Pro-paF, H-Pro-His, Ac-Tyr, Ac-NA, Ac-Trp, Ac-YOM, Ac-Phe, Ac-paF, H-His, Ac-His or Ac-Gly-Tyr-YOM, X1 is Pro Ser or A...

Full description

Saved in:
Bibliographic Details
Main Authors HUI, KWAN Y, LAI, MEI-HUEI T
Format Patent
LanguageEnglish
French
Published 21.05.1991
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:X-8100A The present invention provides antiretroviral methods using the compounds of formula (I) X-Xl-Pl-Val-Z-Leu-P2-Y wherein: Z is Statine or ACHPA; and when Z is Statine, X is H-Pro-paF, H-Pro-His, Ac-Tyr, Ac-NA, Ac-Trp, Ac-YOM, Ac-Phe, Ac-paF, H-His, Ac-His or Ac-Gly-Tyr-YOM, X1 is Pro Ser or Ac, P1 is Phe, paF or YOM, P2 is Phe or Leu, and Y is NH2, paF-NH2, His-NH2, Phe-NH2 or Tyr-LeU-NH2, provided that when X1 is Ac then there is no X residue; and when Z is ACHPA, X is H-Pro-His, H-Pro-paF, Ac paF or Ac-His, P1 is Phe, P2 is Phe, and Y is paF-NH2 and His-NH2. The invention further provides methods for determining the retroviral protease inhibitory activity of compounds using viral polypeptides made using recombinant DNA techniques.
Bibliography:Application Number: CA19902030254