TRIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE

• Main Authors: ITOH, KATSUMI, OKONOGI, KENJI
• Format: Patent
• Language: English; French
• Published: 27.03.1991
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are 2-(2,4-difluorophenyl)-1-(1H-1,2,4- triazol-1-yl)-2-propanol derivatives of the formula: (wherein R0, R1 and R2 are each hydrogen or lower alkyl; A is -S(O)n-X-R3 or -S-R4; n is 0, 1 or 2; R3 is heteroaromatic group; R4 is hydrogen or alkanoyl; X is a bond or -CR5R6-X1-; X1 is a bond or alkylene group; and R5 and R6 are each hydrogen or lower alkyl) useful for preventing or treating infectious diseases cased by fungi. Also disclosed are novel compounds of the formulae: all useful as intermediates for producing the 2-(2,4- difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol derivatives. of the disclosure TRIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE The novel 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol derivertives have antifungal activities, and they are used for preventing or treating infectious diseases caused by fungi.