ANTIHERPES PEPTIDE DERIVATIVES HAVING A 1,4-DIOXO C N-TERMINUS

Disclosed herein are peptide derivatives of the formula R NH-CO-Q-C(O)-NR -CH[CH2C(O)-Y]-C(O)-NH-CH[CR (R )-COOH]-C(W) -NH-CHR -Z wherein R is an optionally substituted alkyl or optionally substituted phenylalkyl, R is hydrogen or alkyl, R and R each independently is hydrogen or alkyl, or R and R ar...

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Bibliographic Details
Main Authors DEZIEL, ROBERT, BEAULIEU, PIERRE L, MOSS, NEIL
Format Patent
LanguageEnglish
Published 12.12.1991
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are peptide derivatives of the formula R NH-CO-Q-C(O)-NR -CH[CH2C(O)-Y]-C(O)-NH-CH[CR (R )-COOH]-C(W) -NH-CHR -Z wherein R is an optionally substituted alkyl or optionally substituted phenylalkyl, R is hydrogen or alkyl, R and R each independently is hydrogen or alkyl, or R and R are joined to form a cycloalkyl, R is alkyl, cycloalkyl or (cycloalkyl)alkyl, Q is a divalent radical, for example, -CH2CH2-, -CH=CH- or 1,2-cyclohexanediyl, which serves as a two carbon spacer, W is oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COOH or CH2OH. The derivatives are useful for treating herpes infections.
Bibliography:Application Number: CA19902018801