PREPARATION OF DIAZABICYCLIC INTERMEDIATES

Diazabicyclo¢2.2.1!heptane intermediates are prepared from 4-hydroxy-L-proline in a five step procedure, or from allo-4-hydroxy-D-proline, through a novel 2-(C1-C6)alkyl-5-substituted-2,5-diazabicyclo-¢2.2.1!heptane intermediate. The diazabicycloheptanes are of use in the preparation of antibiotic q...

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Bibliographic Details
Main Authors BRAISH, TAMIM F, FOX, DARRELL E
Format Patent
LanguageEnglish
French
Published 27.01.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Diazabicyclo¢2.2.1!heptane intermediates are prepared from 4-hydroxy-L-proline in a five step procedure, or from allo-4-hydroxy-D-proline, through a novel 2-(C1-C6)alkyl-5-substituted-2,5-diazabicyclo-¢2.2.1!heptane intermediate. The diazabicycloheptanes are of use in the preparation of antibiotic quinolones.
Bibliography:Application Number: CA19902016343