1-PHENYL-N-/2-CHLORETHYLCARBAMOYL/-7,8-DIMETHOXY-2,3,4,5,- TETRAHYDRO-1H-3-BENZAZEPINS AND METHOD FOR THEIR PREPARATION

( ) SUMMARY OF THE DESCRIPTION The invention concerns 1-phenyl-N-/2-chlorethyl-carbamoyl/-7,8-dimethoxy-2,3,4,5-tetrahydro,-1H-3-benzazepins racemate and optically active isomers with formula 2 and method for their preparation. The compounds with formula 2 show high inhibiting effect on dopamine and...

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Bibliographic Details
Main Authors VASSILEVA, RAINA S, ANGELOVA, IVANKA G, IVANOV, CHAVDAR B, IVANOVA, NEDYALKA S, MANEVA, KATERINA M, MONDESHKA, DONKA M
Format Patent
LanguageEnglish
French
Published 06.10.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:( ) SUMMARY OF THE DESCRIPTION The invention concerns 1-phenyl-N-/2-chlorethyl-carbamoyl/-7,8-dimethoxy-2,3,4,5-tetrahydro,-1H-3-benzazepins racemate and optically active isomers with formula 2 and method for their preparation. The compounds with formula 2 show high inhibiting effect on dopamine and noradrenaline uptake, and the most active is the right rotating isomer /+/-2. The racemic 2 possesses moderate untiulcer activity in experimental model of stress induced stomach ulcers in rats. The left rotating isomer /-/-2 shows direct cytostatic effect on tumour cells from ascite tumour of Erlich /ATE/ and leucosis L1210.
Bibliography:Application Number: CA19902014046