ANXIOLYTICALLY ACTIVE PIPERAZINE DERIVATIVES

• Main Authors: MOS, JOHANNES, HARTOG, JAN
• Format: Patent
• Language: English; French
• Published: 08.06.1990
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

DIR 0425 The invention relates to a group of new piperazine derivatives having formula 1 (1) wherein - R1 and R2 independently of each other are hydrogen or an alkyl group having 1-3 C atoms, - n has the value 1 or 2, - X is an optionally substituted bicyclic group, - A is a group -CH2-CH2-, -CH2-CH(CH3)- or -CH(CH3)-CH2- - B is an aryl group or a heteroaryl group which may be substituted with one or more of the following substituents: halogen, trifluoromethyl, nitrile, alkoxy having 13 C-atoms, hydroxy, esterified hydroxy, or alkyl having 1-4 C-atoms, or wherein B is a straight or branched alkyl group having 3-10 C atoms, or a saturated or a partly unsaturated cycloalkyl group having 4-10 carbon atoms or an optionally substituted aralkyl, or an optionally sustituted heteroaralkyl, and salts thereof. These compounds have psychotropic, and more in particular good anxiolytic properties without the blood pressure being reduced.