ANXIOLYTICALLY ACTIVE PIPERAZINE DERIVATIVES

DIR 0425 The invention relates to a group of new piperazine derivatives having formula 1 (1) wherein - R1 and R2 independently of each other are hydrogen or an alkyl group having 1-3 C atoms, - n has the value 1 or 2, - X is an optionally substituted bicyclic group, - A is a group -CH2-CH2-, -CH2-CH...

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Bibliographic Details
Main Authors MOS, JOHANNES, HARTOG, JAN
Format Patent
LanguageEnglish
French
Published 08.06.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:DIR 0425 The invention relates to a group of new piperazine derivatives having formula 1 (1) wherein - R1 and R2 independently of each other are hydrogen or an alkyl group having 1-3 C atoms, - n has the value 1 or 2, - X is an optionally substituted bicyclic group, - A is a group -CH2-CH2-, -CH2-CH(CH3)- or -CH(CH3)-CH2- - B is an aryl group or a heteroaryl group which may be substituted with one or more of the following substituents: halogen, trifluoromethyl, nitrile, alkoxy having 13 C-atoms, hydroxy, esterified hydroxy, or alkyl having 1-4 C-atoms, or wherein B is a straight or branched alkyl group having 3-10 C atoms, or a saturated or a partly unsaturated cycloalkyl group having 4-10 carbon atoms or an optionally substituted aralkyl, or an optionally sustituted heteroaralkyl, and salts thereof. These compounds have psychotropic, and more in particular good anxiolytic properties without the blood pressure being reduced.
Bibliography:Application Number: CA19892004670