CYCLOALKYLAMIDES OF (8B)-1ALKYL-6 (SUBSTITUTED)ERGOLINES

• Main Authors: MARZONI, GIFFORD PURNELL, FOREMAN, MARK MORTENSEN, WHITTEN, KATHLEEN ROSE, GARBRECHT, WILLIAM LEE
• Format: Patent
• Language: English; French
• Published: 10.02.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention provides (8.beta.)-N-cycloalkyl-1-alkyl-6-(substituted)ergoline-8-carboxamides useful for blocking 5HT2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm,...