BIOABSORBABLE POLYDEPSIPEPTIDES, THEIR PREPARATION AND USE

Disclosed are semi-crystalline depsipeptide polymers and copolymers particularly suitable for use in fabricating bioabsorbable medical implant devices such as sutures or clips and obtained through ring-opening polymerization of 3-substituted-2,5-morpholinediones of the formula: (wherein R is alkyl,...

Full description

Saved in:
Bibliographic Details
Main Authors GLOWAKY, RAYMOND CHARLES, FUNG, FU-NING
Format Patent
LanguageEnglish
French
Published 03.12.1996
Edition6
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
CHEMISTRY
COMPOSITIONS BASED THEREON
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Online AccessGet full text

Cover

More Information
Summary:Disclosed are semi-crystalline depsipeptide polymers and copolymers particularly suitable for use in fabricating bioabsorbable medical implant devices such as sutures or clips and obtained through ring-opening polymerization of 3-substituted-2,5-morpholinediones of the formula: (wherein R is alkyl, alkoxyalkyl, aryl, arylalkyl, alkylaryl, alkylarylalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, cyanoalkyl or aminocarbonylalkyl). The 3substituted-2,5-morpholinediones are prepared by reacting a naturally occurring alpha-amino acid H2N-CH(R)-COOH with an alphahalo acid chloride X-CH2CO-X in inert solvent in the presence of an acid acceptor.
Bibliography:Application Number: CA19880586560